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Identification of the KCNJ10 mutation in dogs with spinocerebellar ataxia with myokymia, seizures, or both clarifies the multiple forms of ataxia seen in these breeds and provides a DNA test to identify carriers.Įpilepsy Kir4.1 Peripheral nerve hyperexcitability Potassium channel.Ĭopyright © 2014 The Authors Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. Dogs homozygous for the mutant allele all had spinocerebellar ataxia with varying combinations of myokymia and seizures. Most of the time, this will begin with the socialization process and potty training. It is essential to begin the process right away. This allele was identified in a whole-genome sequence of a single RGT with spinocerebellar ataxia and myokymia by comparison to whole-genome sequences from 81 other canids that were normal or had other diseases.Ī missense mutation in the gene coding for the inwardly rectifying potassium channel Kir4.1 (KCNJ10:c.627C>G) was significantly (P <. Training is essential for any dog breed, and that 100 includes your new Jack Russell.
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This case-control study compared the frequencies of a KCNJ10 allele in RGTs with spinocerebellar ataxia versus control RGTs. The objective was to identify the mutation causing the spinocerebellar ataxia associated with myokymia, seizures, or both and distinguish the phenotype from other ataxias in the RGTs.ĭNA samples from 16 RGTs with spinocerebellar ataxia beginning from 2 to 12 months of age, 640 control RGTs, and 383 dogs from 144 other breeds along with the medical records of affected dogs were studied. More than 1 form of the disease has been suspected. Ataxia occurs with varying combinations of myokymia, seizures, and other signs of neurologic disease. The Russell Terrier originated in England. Juvenile-onset spinocerebellar ataxia has been recognized in Jack Russell Terriers and related Russell group terriers (RGTs) for over 40 years. The ancestry of the breed combines the ultimate size, instinct, and construction for the working earth terrier.